The Mona Lisa Touch is a fractionated CO2 laser that has been in use in Europe since 2008. It was approved for use in the U.S. by the FDA in 2014.
We make small “injuries” surrounded by normal tissue and the body sends in immune cells to start the inflammation and healing. During the healing process the rejuvenating cells in the vaginal tissue, called fibrocytes, reawaken and become fibroblasts and start to make normal components of pre-menopausal vaginal tissue such as collagen, glycogen, and hyaluronic acid. This causes the vaginal tissues to plump up and become thicker and more hydrated. The glycogens and hyaluronic acid return the inside of the vagina to a normal pH and encourage the normal bacteria (primarily lactobacilli) to return. This, in turn, helps reduce chronic vaginal and urinary infections that can be irritating in menopause. There are excellent studies showing all of these effects available in the medical literature.
Zerbinati N, et al. Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment; Lasers Med Sci 2014 (pub. on-line)
Athanasiou, S et al. The effect of microablative CO2 laser on the microflora of postmenopausal women. Climacteric 2016: Oct 19(5) 512-8.